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London, United Kingdom

What are the risks of hyaluronidase? Surely it dissolves natural hyaluronic acid too? Can find little info online..

I had cheek injections with Restylane 3 weeks ago and now hate it as it has caused significant water retention in my cheeks. Hyaluronidase is bandied around as a 'quick easy' fix to unwanted restylane, but it seems to my mind a dangerous thing to be injecting something which is not FDA approved for the purpose and surely dissolves your own hyaluronic acid too - potentially causing long term damage? I would be grateful for any advice in this regard, as there is a strange lack of info/review on hyaluronidase online. Many thanks

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Doctor/Professional Answers (3)   


Plastic surgeon
Miami, FL
United States
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November 18, 2011 3:44 AM

I ALWAYS do very small droplets amounts in weekly sessions to avoid any excess resolution. (more)
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Facial plastic surgeon
Bellevue, WA
United States
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  hyaluronidase and restylane injections
November 17, 2011 5:25 PM

Hyaluronidase will degrade the unwanted restylane and it can degrade your own hyaluronic acid. But your body is programmed to make your natural hyaluronic acid again. So the long term (more)

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hyaluronidase and restylane injections

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Plastic surgeon
los angeles, CA
United States
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  safe in my experience
July 23, 2009 4:20 PM

i have been using hyaluronidase for several years now. i have used it on several hundred patients and have seen no problems that i could directly relate to the enzyme. i am quite (more)
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Member Comments (2)

January 20, 2018 5:37 AM

I had it in my nose and lip and chin 0.5 ml and it had spreaded all over my face and couldn?t go out for four days, now my face and my skin have been ruined because of it I believe that it has removed a lot from the natural HA in my face actually even my eyelids are different I used to be pretty and now I don?t know what is the solution , I tried to put filler in my lips but it doesn?t look as good as before having the Hyaluoridase

September 17, 2017 7:51 AM

Hello, my daughter had belotero filler which dont work out she got very distressed and had it reversed by another cosmectic doctor. After her face seemed to go quite thin he put in 800IU,do you think this as too much as she only had a very small amount of filler and can the hyaluronidase destroyed your natural HA is she now permanently damaged? will the body make it back, help!



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